Mediated Gene Regulation For Cancer Therapy Essay

MicroRNA-mediated Gene Regulation Alex Almazan Animal, Rangeland, and Wildlife Sciences Department, Texas AM University Kingsville December 5, 2016 MicroRNA-mediated Gene Regulation Introduction MicroRNAs are short regulatory RNAs that modulate gene expression and are expressed in many diseases, including cancer. Studies have shown that microRNAs inhibit the translation and facilitate degradation of their targeted messenger RNAs which makes them a great candidate for the use in cancer therapy (Shahab, 2011, p. 1). Many researchers and scientists are especially finding ways microRNAs can help with epithelial ovarian cancer in means by examining their expression pattern and mechanistic implications of microRNA-383 in which these captivating particles can modify the appearance of almost 30% of the Performing at the post-transcriptional mammalian protein-encoding genes. In this unique process, cells can be known to be complex because of the different functions that are taken upon. Due to the fact that cells have specific functions, in order for it to have the proper genes expressed, gene regulation is enforced throughout the early stages of development in a cell; this enforcemen t signals that each gene be expressed properly and at the proper time. Because of this process, living organisms are able to respond to each individual environment. The deadliest form of cancer among female patients in the world is epithelial ovarian cancer. The latest study conducted in theShow MoreRelatedCOX-2 And Sp4 Case Study1547 Words   |  7 Pagesroles of COX-2 and EP4 in human breast cancer progression and SLC induction via PI3K/AKT/NOTCH and WNT pathways, combining in vitro, in vivo, and in situ approaches. This work supports our previous studies, wherein we showed SLC stimulatory roles of COX-2 and EP4 in a murine breast cancer model [5]. The role of COX-2 in SLC induction has been hypothesized [42] and the roles of EP4 documented in human breast cancer cells [43]. 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